Description

L-Methionine Allyl Ester Toluene-4-Sulfonate is a specialized, high-purity chemical intermediate primarily used in advanced organic synthesis. This compound is critical for the controlled introduction of the methionine moiety in peptide and active pharmaceutical ingredient (API) manufacturing. It is an essential building block for researchers and production chemists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for complex synthetic pathways.

Application

• Peptide Synthesis: A key protected amino acid derivative for solid-phase and solution-phase peptide synthesis, particularly for incorporating methionine residues.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of novel APIs and therapeutic compounds.
• Bioconjugation Chemistry: Used in the development of antibody-drug conjugates (ADCs) and other bioconjugates due to its reactive allyl ester group.
• Protecting Group Strategy: The tosylate and allyl ester groups offer orthogonal protection/deprotection routes in multi-step organic syntheses.
• Research & Development: A valuable reagent for medicinal chemistry and process chemistry research in academic and industrial laboratories.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	L-Methionine Allyl Ester Toluene-4-Sulfonate
CAS No.	142601-87-4
Molecular Formula	C15H23NO5S2
Molecular Weight	361.48 g/mol
Synonyms	L-Methionine allyl ester p-toluenesulfonate; Allyl L-methioninate p-toluenesulfonate; (S)-2-Amino-4-(methylthio)butanoic acid allyl ester 4-methylbenzenesulfonate; Methionine allyl ester tosylate; L-Met-OAll·TosOH; Tosic acid salt of L-methionine allyl ester; 4-Methylbenzenesulfonic acid compound with allyl (2S)-2-amino-4-(methylsulfanyl)butanoate (1:1)
EINECS	Contact for details

Quality Control

Our L-Methionine Allyl Ester Toluene-4-Sulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, enantiomeric purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	Specific range provided on COA
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.