Description

6-(Benzyloxy)-9-((1S,3S)-4-(Benzyloxy)-3-((Benzyloxy)Methyl)-2-Methylenecyclopentyl)-n-((4-Methoxyphenyl)Diphenylmethyl)-9H-Purin-2-Amine is a sophisticated, high-purity nucleoside analog intermediate of significant importance in advanced pharmaceutical synthesis. This compound is engineered to serve as a critical building block in the development of novel antiviral and anticancer therapeutics, where precise stereochemistry and functional group protection are paramount. It is primarily required by research institutions and pharmaceutical companies engaged in the synthesis of modified purine derivatives and prodrug development.

Application

• Pharmaceutical Intermediate: A key protected precursor in the multi-step synthesis of nucleoside-based active pharmaceutical ingredients (APIs).
• Antiviral Drug Research: Used in the research and development of novel antiviral agents targeting viral polymerases.
• Oncology Research: Serves as a building block for creating purine analogs investigated for their antiproliferative and chemotherapeutic potential.
• Prodrug Synthesis: Utilized in the design and synthesis of prodrugs to enhance the bioavailability and targeting of nucleotide analogs.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme kinetics and inhibition mechanisms involving purine metabolism.
• Process Chemistry & Scale-Up: Supports process development and optimization for the commercial-scale manufacturing of specialty pharmaceuticals.

Basic Information

Product Name	6-(Benzyloxy)-9-((1S,3S)-4-(Benzyloxy)-3-((Benzyloxy)Methyl)-2-Methylenecyclopentyl)-n-((4-Methoxyphenyl)Diphenylmethyl)-9H-Purin-2-Amine
CAS No.	142217-80-9
Molecular Formula	C56H52N6O4
Molecular Weight	873.06 g/mol
Synonyms	9H-Purin-2-amine, 6-(benzyloxy)-9-[(1S,3S)-4-(benzyloxy)-3-[(benzyloxy)methyl]-2-methylenecyclopentyl]-N-[(4-methoxyphenyl)diphenylmethyl]-; 6-Benzyloxy-9-[(1S,3S)-4-benzyloxy-3-(benzyloxymethyl)-2-methylenecyclopentyl]-N-(4-methoxytriphenylmethyl)-9H-purin-2-amine; Protected Adenine Nucleoside Intermediate; N-MMTr-6-O-Bn-9-[(1S,3S)-4-O-Bn-3-(BnO-CH2)-2-methylenecyclopentyl]adenine; (1S,3S)-4-(Benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl 6-(benzyloxy)-2-((4-methoxyphenyl)diphenylmethylamino)purine-9-carboxylate (tautomeric form).
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to confirm identity, chiral purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.