Description

1-(2',5'-Bis-o-(tert-Butyldimethylsilylribofuranosyl)-3-n-Methylthymine)-3'-Spiro-5''-(4''-Amino-1'',2''-Oxathiole-2'',2''-Dioxide) is a sophisticated, high-purity nucleoside analog derivative, specifically engineered for advanced pharmaceutical research and development. This compound is critical for its role as a key synthetic intermediate in the production of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases and cellular replication mechanisms. It is an essential material for research institutions, biotechnology firms, and pharmaceutical companies engaged in the synthesis of modified oligonucleotides and prodrug development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of next-generation antiviral and anticancer nucleotide analogs.
• Antiviral Drug Development: Used in research targeting viruses such as Hepatitis C (HCV), HIV, and other RNA viruses by acting as a polymerase inhibitor precursor.
• Prodrug Synthesis: Serves as a protected, activated nucleoside for creating prodrugs with enhanced bioavailability and targeted delivery.
• Oligonucleotide Chemistry: Employed in solid-phase and solution-phase synthesis of modified DNA/RNA strands for therapeutic and diagnostic applications.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to understand polymerase mechanisms and nucleotide metabolism.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize potency and reduce toxicity of nucleoside-based drugs.

Basic Information

Product Name	1-(2',5'-Bis-o-(tert-Butyldimethylsilylribofuranosyl)-3-n-Methylthymine)-3'-Spiro-5''-(4''-Amino-1'',2''-Oxathiole-2'',2''-Dioxide)
CAS No.	142102-79-2
Molecular Formula	C33H57N3O9SSi2
Molecular Weight	719.1 g/mol
Synonyms	3'-Spiro-5''-(4''-Amino-1'',2''-oxathiole 2'',2''-dioxide) Derivative of 1-[2',5'-Bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine; 1-[2',5-Bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3-N-methylthymine 3'-Spiro-5''-(4''-amino-δ²-1,2,4-oxathiazoline 2,2-dioxide); TBDMS-protected Spiro Nucleoside; 3-N-Methylthymidine Spirocyclic Sulfamate Derivative; Nucleoside Spirocyclic Sulfamoylating Agent; Antiviral Nucleoside Intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict cGMP guidelines to ensure batch-to-batch consistency and traceability for pharmaceutical applications. Identity, purity, and impurity profiles are rigorously verified using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The compound is moisture-sensitive; containers should be allowed to equilibrate to room temperature before opening to prevent condensation. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.