Description

L-Proline, 2-Carboxyhydrazide (9Ci) is a specialized proline derivative that serves as a versatile building block in advanced organic synthesis. This compound is valued for its unique bifunctional structure, incorporating both a carboxylic acid hydrazide and a proline backbone, which enables its use in constructing complex molecular architectures. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for applications in medicinal chemistry and as a precursor for heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics and constrained peptides to improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the development of new generation herbicides and plant growth regulators with specific modes of action.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Cross-linking Agent: Its hydrazide functionality allows it to act as a linker or cross-linking agent in polymer and material science.
• Bioconjugation Chemistry: Useful in bioconjugation strategies for attaching probes, drugs, or other molecules to proteins or other biomolecules.

Basic Information

Product Name	L-Proline, 2-Carboxyhydrazide (9Ci)
CAS No.	141873-57-6
Molecular Formula	C6H11N3O3
Molecular Weight	173.17 g/mol
Synonyms	L-Proline hydrazide; (S)-2-Carboxyhydrazide pyrrolidine-2-carboxylic acid; 2-Hydrazinyl-2-oxoethyl-L-proline; Proline, 2-carboxyhydrazide, L-; Prolinecarbohydrazide; L-Pyrolidine-2-carboxylic acid, 2-carboxyhydrazide; (2S)-1-(2-Hydrazinyl-2-oxoethyl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our L-Proline, 2-Carboxyhydrazide is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep the container tightly sealed when not in use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.