Description

Methyl 1-Cyclopropyl-6,7-Difluoro-8-Methoxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of modern fluoroquinolone antibiotics, offering a direct pathway to active pharmaceutical ingredients (APIs) with enhanced efficacy. It is essential for R&D laboratories and manufacturing facilities focused on developing and producing next-generation antibacterial agents.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Primary building block in the synthesis of gatifloxacin, prulifloxacin, and other third/fourth-generation quinolone antimicrobials.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design, optimization, and scale-up of novel antibacterial compounds.
• Active Pharmaceutical Ingredient (API) Manufacturing: Integrated into regulated GMP processes for the commercial production of finished dosage forms.
• Chemical Synthesis Studies: Serves as a model substrate in academic and industrial research exploring new synthetic methodologies for heterocyclic compounds.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory testing of antibiotic products.

Basic Information

Product Name	Methyl 1-Cyclopropyl-6,7-Difluoro-8-Methoxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate
CAS No.	141290-02-0
Molecular Formula	C15H13F2NO4
Molecular Weight	309.27 g/mol
Synonyms	1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid methyl ester; Methyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate; Gatifloxacin intermediate; AM-1155 intermediate; Q-35 intermediate; 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 1-Cyclopropyl-6,7-Difluoro-8-Methoxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate is manufactured under strict quality systems to meet the exacting standards of the pharmaceutical industry. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant ICH guidelines and can tailor specifications to meet specific customer requirements for pharmaceutical development and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to exclude moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.