Description

Tr-PEG6 is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a triazole (Tr) group and a six-unit PEG spacer. This compound is essential for creating stable, water-soluble conjugates in advanced bioconjugation and materials science applications. It is particularly valuable for researchers and manufacturers in the pharmaceutical, diagnostic, and nanotechnology sectors who require precise and reliable crosslinking agents. The product is supplied under high-purity conditions to ensure optimal performance in sensitive synthetic workflows.

Application

• Bioconjugation Reagent: Used for linking biomolecules such as peptides, proteins, and oligonucleotides to surfaces, nanoparticles, or other functional molecules.
• ADC (Antibody-Drug Conjugate) Development: Serves as a crucial linker component in the synthesis of next-generation ADCs, leveraging click chemistry for stable drug attachment.
• Polymer and Materials Science: Acts as a hydrophilic spacer to modify the properties of polymers, hydrogels, and surfaces, enhancing biocompatibility and solubility.
• Diagnostic Assay Development: Employed in the fabrication of biosensors and diagnostic probes where controlled and specific immobilization is required.
• Drug Delivery Systems: Incorporated into nanocarriers and liposomes to functionalize surfaces for targeted delivery applications.
• Click Chemistry Platforms: A key building block in Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and other bioorthogonal reactions.

Basic Information

Product Name	Tr-PEG6
CAS No.	141282-24-8
Molecular Formula	C23H43N3O8
Molecular Weight	489.61 g/mol
Synonyms	1-(1,2,3-Triazol-4-yl)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid; Triazole-PEG6-acid; 4-(21-Carboxy-3,6,9,12,15,18-hexaoxahenicos-1-yn-1-yl)-1H-1,2,3-triazole; Tr-PEG6-COOH; Heterobifunctional PEG linker, Triazole terminated; PEG6-triazole-acid; Azide-PEG6-acid (precursor related); 1,2,3-Triazol-4-yl-PEG6-COOH
EINECS	Contact for details

Quality Control

Our Tr-PEG6 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment ensures the material meets the high standards required for research and cGMP-grade manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store the product under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. For long-term stability, we recommend storage at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.