Description

1,4-Dioxaspiro[4.5]Decan-8-Yl Methanesulfonate is a high-purity chemical intermediate featuring a protected carbonyl group activated by a methanesulfonate (mesylate) leaving group. This compound is critically valuable for its role in sophisticated organic synthesis, enabling precise carbon-carbon and carbon-heteroatom bond formation under mild conditions. It is primarily sought after by research institutions and pharmaceutical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and complex, functionalized molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates, particularly those containing spirocyclic or bridged ring systems.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where specific stereochemistry and functional group manipulation are required.
• Material Science Research: Serves as a precursor for creating novel polymers, ligands, or organic frameworks with tailored properties.
• Academic & Process Chemistry: Employed in methodological studies and scale-up processes for introducing the 1,4-dioxaspiro[4.5]decan-8-yl moiety into target molecules.
• Fine Chemical Production: Integral to the manufacture of specialty chemicals, flavors, and fragrances that require high-purity, structurally defined intermediates.

Basic Information

Product Name	1,4-Dioxaspiro[4.5]Decan-8-Yl Methanesulfonate
CAS No.	141120-33-4
Molecular Formula	C11H20O5S
Molecular Weight	264.34 g/mol
Synonyms	8-Methanesulfonyloxy-1,4-dioxaspiro[4.5]decane; 1,4-Dioxaspiro[4.5]decan-8-yl mesylate; 8-(Methylsulfonyloxy)-1,4-dioxaspiro[4.5]decane; Spiro[1,3-dioxolane-2,1'-cyclohexane]-4'-yl methanesulfonate; 8-Hydroxy-1,4-dioxaspiro[4.5]decane 8-methanesulfonate; Cyclohexanone ethylene ketal 8-mesylate
EINECS	Contact for details

Quality Control

Every batch of 1,4-Dioxaspiro[4.5]Decan-8-Yl Methanesulfonate is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency meet the high standards required for research and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.