Description

(2R,3S)-β-p-Chlorophenylglutamic Acid is a high-purity, stereochemically defined chiral building block and pharmaceutical intermediate. This compound is critical for the research and development of targeted therapeutics, particularly in the fields of neurology and metabolic disorders. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in advanced medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates targeting glutamate receptors.
• Neurological Research: Used in the development of compounds for studying and treating conditions like epilepsy, neuropathic pain, and neurodegenerative diseases.
• Metabolic Disorder Research: Serves as a precursor in the development of potential therapies for metabolic syndromes.
• Asymmetric Synthesis: Valuable chiral pool material for constructing complex molecules with defined stereochemistry in organic synthesis.
• Biochemical Tool Compound: Employed in enzymatic studies and as a standard for analytical method development in bioanalysis.
• Process Chemistry & Scale-up: Used in the optimization and pilot-scale production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2R,3S)-β-p-Chlorophenylglutamic Acid
CAS No.	140924-23-8
Molecular Formula	C11H12ClNO4
Molecular Weight	257.67 g/mol
Synonyms	(2R,3S)-3-(4-Chlorophenyl)glutamic Acid; (2R,3S)-β-(4-Chlorophenyl)glutamic Acid; (2R,3S)-4-Chlorophenylglutamic Acid; (2R,3S)-p-Chlorophenylglutamic Acid; (2R,3S)-3-(p-Chlorophenyl)glutamic Acid; (2R,3S)-BOC-p-Chlorophenylglutamic Acid (protected form); (2R,3S)-CPG; L-threo-β-(4-Chlorophenyl)glutamic Acid
EINECS	Contact for details

Quality Control

Our (2R,3S)-β-p-Chlorophenylglutamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) and chemical purity, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.