Description

8-Chloro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine is a high-value heterocyclic building block containing both chlorine and trifluoromethyl functional groups. This compound matters as a critical intermediate for the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique scaffold imparts desirable biological activity and metabolic stability. Pharmaceutical and agrochemical R&D teams need it to develop new drug candidates and crop protection agents targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new small molecule drugs, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the triazolopyrazine core.
• Material Science Research: Serves as a precursor for developing specialty chemicals, dyes, and functional materials with specific electronic properties.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tagging agent in the design of chemical probes for studying biological pathways.
• Academic & Contract Research: Essential for universities and CROs (Contract Research Organizations) conducting fundamental research in medicinal and synthetic organic chemistry.

Basic Information

Product Name	8-Chloro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine
CAS No.	140911-31-5
Molecular Formula	C6H2ClF3N4
Molecular Weight	222.55 g/mol
Synonyms	8-Chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine; 8-Chloro-3-trifluoromethyl-[1,2,4]triazolo[4,3-a]pyrazine; 140911-31-5; 8-Chloro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine; 8-Chloro-3-(trifluoromethyl)-1H-[1,2,4]triazolo[4,3-a]pyrazine; 8-Chloro-3-(trifluoromethyl)-1,2,4-triazolopyrazine; 3-(Trifluoromethyl)-8-chloro-[1,2,4]triazolo[4,3-a]pyrazine
EINECS	Contact for details

Quality Control

Our 8-Chloro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, impurities, and full characterization data are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.