Description

R(+)-6-Bromo-7,8-Dihydroxy-3-Allyl-1-Phenyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine Hydrobromide is a high-purity, chiral benzazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmacological reference standard and a key synthetic intermediate for the study of dopamine receptor activity and related neurological pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in neuroscience and medicinal chemistry.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in drug discovery pipelines.
• Dopamine Receptor Research: Acts as a key ligand and tool compound in biochemical assays to study D1 and D5 dopamine receptor subtypes.
• Medicinal Chemistry Intermediate: Serves as a chiral building block for the synthesis of novel dopaminergic agents and potential therapeutics.
• Neuroscience Studies: Employed in vitro and in vivo research to investigate neurological disorders, behavior, and signal transduction mechanisms.
• Process Chemistry Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) targeting the central nervous system.

Basic Information

Item	Detail
Product Name	R(+)-6-Bromo-7,8-Dihydroxy-3-Allyl-1-Phenyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine Hydrobromide
CAS No.	139689-19-3
Molecular Formula	C19H20BrNO2 • HBr
Molecular Weight	455.19 g/mol
Synonyms	(6aR)-6-Bromo-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide; R(+)-SKF-82958 hydrobromide; (R)-6-Bromo-APB hydrobromide; R(+)-6-Bromo-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine HBr; R(+)-6-Br-APB HBr; SKF 82958 HBr (R-enantiomer); Dopamine D1 receptor full agonist (R-form)
EINECS	Contact for details

Quality Control

Our R(+)-6-Bromo-7,8-Dihydroxy-3-Allyl-1-Phenyl-2,3,4,5-Tetrahydro-1H-3-Benzazepine Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR, and mass spectrometry for structural confirmation, to ensure compliance with research-grade standards. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.