Description

(R)-6-Methoxy-2,5,7,8-Tetramethylchromane-2-Carboxylic Acid CAS NO 139658-04-1 is a high-purity, single-enantiomer derivative of Vitamin E, specifically the (R)-enantiomer of Trolox. This compound is a potent, water-soluble antioxidant and serves as a critical chiral building block and reference standard in advanced research and synthesis. It is essential for industries requiring precise stereochemical control and reliable antioxidant performance, including pharmaceutical development, nutraceutical formulation, and advanced material science.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control of chiral pharmaceutical compounds.
• Antioxidant Research: A key reagent in biochemical and pharmacological studies to investigate oxidative stress, lipid peroxidation, and free radical scavenging mechanisms.
• Nutraceutical & Cosmetic Ingredient: Incorporated into high-end formulations for its stabilized, potent antioxidant properties to enhance product efficacy and shelf-life.
• Chiral Synthesis: Serves as a valuable chiral intermediate or starting material for the synthesis of complex, biologically active molecules and novel chemical entities.
• Food Science: Applied in research to study antioxidant effects in food preservation and fortification.
• Polymer Stabilization: Used as an additive to prevent oxidative degradation in specialty polymers and advanced materials.

Basic Information

Product Name	(R)-6-Methoxy-2,5,7,8-Tetramethylchromane-2-Carboxylic Acid
CAS No.	139658-04-1
Molecular Formula	C15H20O4
Molecular Weight	264.32 g/mol
Synonyms	(R)-Trolox; (R)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid; (R)-Trolox Methyl Ether; (2R)-6-Methoxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylic Acid; (R)-Enantiomer of Trolox Methyl Ether; (R)-6-O-Methyl-Trolox; Antioxidant (R)-Trolox derivative; (2R)-6-Methoxy-2,5,7,8-tetramethyl-2H-chromene-2-carboxylic Acid
EINECS	Contact for details

Quality Control

We supply (R)-6-Methoxy-2,5,7,8-Tetramethylchromane-2-Carboxylic Acid in high-purity grades suitable for research and commercial applications. Our products undergo rigorous quality testing to ensure compliance with industry standards, including chiral purity and chemical identity verification. Certificates of Analysis (COA) detailing specific lot results for assay, enantiomeric excess, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.