Description

4(1H)-Quinazolinone, 3-(2-(4-(4-Nitrobenzoyl)-1-Piperidinyl)Ethyl)-2,3-Dihydro-2-Thioxo- is a specialized heterocyclic organic compound that serves as a critical advanced intermediate in modern pharmaceutical research and development. Its complex molecular architecture, featuring quinazolinone and piperidine moieties, makes it a valuable scaffold for synthesizing novel bioactive molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery of new therapeutic agents, particularly for applications in oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates targeting specific enzymes or receptors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Kinase Inhibitor Development: Serves as a precursor in the creation of novel kinase inhibitors for cancer therapy research.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein functions.
• Custom Synthesis: Employed by contract research organizations (CROs) and CDMOs for client-specific synthetic routes.
• Academic Research: Used in university laboratories for exploratory research in organic synthesis and pharmacology.

Basic Information

Item	Detail
Product Name	4(1H)-Quinazolinone, 3-(2-(4-(4-Nitrobenzoyl)-1-Piperidinyl)Ethyl)-2,3-Dihydro-2-Thioxo-
CAS No.	139418-53-4
Molecular Formula	C22H22N4O3S
Molecular Weight	422.50 g/mol
Synonyms	3-[2-[4-(4-Nitrobenzoyl)piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one; 3-(2-(4-(4-Nitrobenzoyl)-1-piperazinyl)ethyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone; 139418-53-4; 4(1H)-Quinazolinone, 3-(2-(4-(4-nitrobenzoyl)-1-piperazinyl)ethyl)-2,3-dihydro-2-thioxo-; 2-Thioxo-3-[2-[4-(4-nitrobenzoyl)piperidino]ethyl]-4(1H)-quinazolinone
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing specifications for assay, related substances, and residual solvents. We support cGMP-compliant manufacturing for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.