Description

2-((3R,5R)-3,5-Bis(tert-Butyldimethylsilyloxy)Cyclohexylidene)Ethanol is a high-purity, chiral synthetic intermediate featuring a protected diol functionality. This compound is critically important for its role in the stereoselective synthesis of complex organic molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing key molecular scaffolds. The product is supplied with guaranteed batch-to-batch consistency to ensure reliable results in sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those with complex polycyclic or steroid-like structures.
• Asymmetric Synthesis: Utilized in stereocontrolled reactions to introduce specific stereocenters, crucial for developing enantiomerically pure drugs.
• Natural Product Synthesis: Serves as a precursor in the total synthesis of complex natural products where the protected cyclohexylidene ethanol moiety is a structural component.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes during the transition from laboratory to pilot plant and commercial manufacturing.
• Agrochemical Research: Employed in the development of new chiral pesticides and herbicides where specific stereochemistry impacts biological activity.
• Material Science Precursor: Potential use in the synthesis of specialized ligands for catalysis or advanced organic materials.

Basic Information

Product Name	2-((3R,5R)-3,5-Bis(tert-Butyldimethylsilyloxy)Cyclohexylidene)Ethanol
CAS No.	139356-37-9
Molecular Formula	C20H42O3Si2
Molecular Weight	386.72 g/mol
Synonyms	(3R,5R)-3,5-Bis[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-cyclohexylidene-1-ethanol; 2-[(3R,5R)-3,5-Bis[[tert-butyl(dimethyl)silyl]oxy]cyclohexylidene]ethanol; (3R,5R)-3,5-Bis-O-(tert-butyldimethylsilyl)-2-cyclohexylideneethanol; TBS-protected (3R,5R)-Cyclohexylideneethanol; Chiral TBS Diol Derivative; (3R,5R)-Bis-TBS-oxy-2-cyclohexylideneethanol
EINECS	Contact for details

Quality Control

Our 2-((3R,5R)-3,5-Bis(tert-Butyldimethylsilyloxy)Cyclohexylidene)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.