Description

Hydroxy-Peg3-Mes CAS NO 139115-89-2 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a hydroxyl group and a methylsulfonate ester (mesylate) group, separated by a triethylene glycol spacer. This molecular architecture makes it a versatile and critical linker for bioconjugation and pharmaceutical development, enabling the controlled attachment of bioactive molecules. It is primarily utilized by researchers and manufacturers in biopharmaceuticals, proteomics, and advanced material science for creating PEGylated therapeutics, diagnostic probes, and functionalized surfaces.

Application

• Bioconjugation and PEGylation: A key reagent for attaching drugs, proteins, or peptides to PEG chains to improve solubility, stability, and pharmacokinetic profiles.
• Antibody-Drug Conjugate (ADC) Linker: Serves as a functional spacer in the synthesis of ADCs, connecting cytotoxic payloads to monoclonal antibodies.
• Crosslinking Agent: Used to create stable covalent bonds between molecules containing complementary functional groups (e.g., amines, thiols) in material science and biochemistry.
• Polymer Chemistry Intermediate: Acts as a building block for synthesizing more complex functionalized PEGs and block copolymers.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, and chromatographic media with hydrophilic PEG layers to reduce non-specific binding.
• Prodrug Synthesis: Facilitates the design of prodrugs where the active pharmaceutical ingredient is released upon specific biological conditions.

Basic Information

Product Name	Hydroxy-Peg3-Mes
CAS No.	139115-89-2
Molecular Formula	C10H22O7S
Molecular Weight	286.34 g/mol
Synonyms	3-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]propyl methanesulfonate; 1-(Methylsulfonyl)-3,6,9-trioxa-11-undecanol; Hydroxy-PEG3-mesylate; HO-PEG3-OMs; 11-Hydroxy-3,6,9-trioxaundecyl methanesulfonate; PEG3-OH Mesylate; Triethylene glycol monomethylsulfonate ether
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg3-Mes is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP manufacturing. Each lot undergoes rigorous analytical testing including NMR, HPLC, and mass spectrometry for identity and purity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, containers should be sealed under an inert atmosphere after opening and allowed to equilibrate to room temperature before use to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.