Description

2,2'-Methylenebis[(4R,5S)-4,5-Diphenyl-2-Oxazoline] is a highly versatile and stereochemically defined chiral bis(oxazoline) ligand. This compound matters because it serves as a critical catalyst component in asymmetric synthesis, enabling the production of enantiomerically pure intermediates essential for advanced pharmaceuticals and fine chemicals. Industries that require high-precision stereoselective transformations, such as pharmaceutical R&D, agrochemical manufacturing, and specialty chemical synthesis, rely on this ligand for its excellent enantioselectivity and stability under various reaction conditions.

Application

• As a chiral ligand in asymmetric cyclopropanation and Diels-Alder reactions.
• Key component in enantioselective catalysis for pharmaceutical intermediate synthesis.
• Used in the preparation of optically active compounds for agrochemicals.
• Facilitates asymmetric alkylation and aldol reactions in academic and industrial research.
• Employed in the synthesis of complex natural products and flavors & fragrances.
• Utilized in the development of novel metal-organic frameworks (MOFs) with chiral pores.

Basic Information

Product Name	2,2'-Methylenebis[(4R,5S)-4,5-Diphenyl-2-Oxazoline]
CAS No.	139021-82-2
Molecular Formula	C33H28N2O2
Molecular Weight	484.59 g/mol
Synonyms	(4R,5S)-4,5-Diphenyl-2,2'-methylenebis[2-oxazoline]; (R,S)-Bis(4,5-diphenyl-2-oxazolin-2-yl)methane; (R,S)-Bis(diphenyloxazolinyl)methane; (R,S)-Bis(DPO)M; Chiral BOX Ligand; (R,S)-Methylene-bis(4,5-diphenyloxazoline); (4R,5S)-DPO-BOX; (R,S)-DPO-BOX Ligand
EINECS	Contact for details

Quality Control

Our 2,2'-Methylenebis[(4R,5S)-4,5-Diphenyl-2-Oxazoline] is produced under strict quality management systems to ensure batch-to-batch consistency and high chiral purity for demanding catalytic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as enantiomeric excess, chemical purity, and residual solvent content. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain its chemical integrity and catalytic performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.