Description

Cocaine (n-Methyl-D3) is a stable isotope-labeled analog of cocaine, specifically deuterated at the N-methyl position. This compound is an essential reference standard and internal standard for analytical and forensic applications, providing unmatched specificity and accuracy in quantitative mass spectrometry. It is primarily required by forensic laboratories, clinical research facilities, and pharmaceutical developers for method validation, drug metabolism studies, and precise quantification in complex matrices.

Application

• Quantitative Analytical Reference Standard: Serves as a critical internal standard for the accurate quantification of cocaine and its metabolites via LC-MS/MS and GC-MS in forensic and clinical toxicology.
• Forensic Analysis & Method Development: Used for calibrating instruments, validating analytical methods, and ensuring reliable results in legal and law enforcement testing.
• Pharmacokinetic & Metabolism Research: Enables detailed studies on the absorption, distribution, metabolism, and excretion (ADME) of cocaine in preclinical and clinical research.
• Doping Control & Sports Drug Testing: Employed as a certified reference material for the unambiguous identification and confirmation of cocaine in athlete biological samples.
• Quality Control in Pharmaceutical Research: Acts as a benchmark for purity and identity in the development of potential therapeutic agents or diagnostic assays related to cocaine.
• Stable Isotope Dilution Assays: Provides the foundation for highly precise and accurate isotope dilution mass spectrometry (IDMS) techniques.

Basic Information

Product Name	Cocaine (n-Methyl-D3)
CAS No.	138704-14-0
Molecular Formula	C17H20D3NO4
Molecular Weight	306.39 g/mol
Synonyms	(1R,2R,3S,5S)-3-(Benzoyloxy)-8-methyl-8-(trideuteriomethyl)-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester; Cocaine-N-CD3; Cocaine-d3 (N-methyl); Benzoylmethylecgonine-d3 (N-methyl); 2β-Carbomethoxy-3β-benzoxytropane-d3; N-Methyl-d3-cocaine; [N-Methyl-d3]cocaine; L-Cocaine-d3 (N-methyl)
EINECS	Contact for details

Quality Control

Every batch of Cocaine (n-Methyl-D3) CAS NO 138704-14-0 is manufactured and analyzed under strict quality systems. The product undergoes rigorous testing, including chromatographic purity analysis and isotopic enrichment verification, to ensure it meets the high standards required for forensic and research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), isotopic purity, and specific tests is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.