Description

1-Oxa-2-Azaspiro[2.5]Octane, 2-Acetyl-5-Methyl-, (3R-Cis)- (9Ci) is a high-purity, chiral spirocyclic compound that serves as a sophisticated building block in advanced organic synthesis. Its unique fused heterocyclic structure makes it a valuable intermediate for constructing complex molecules with precise stereochemistry. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the creation of advanced, stereospecific pesticides and herbicides where the specific 3R-cis configuration can influence biological activity.
• Ligand and Catalyst Development: Serves as a precursor for novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for creating polymers with unique thermal or mechanical properties due to its rigid spiro structure.
• Academic & Industrial R&D: Employed in methodological studies and process chemistry for constructing complex, three-dimensional molecular architectures.

Basic Information

Product Name	1-Oxa-2-Azaspiro[2.5]Octane, 2-Acetyl-5-Methyl-, (3R-Cis)- (9Ci)
CAS No.	138385-69-0
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	(3R-cis)-2-Acetyl-5-methyl-1-oxa-2-azaspiro[2.5]octane; 2-Acetyl-5-methyl-1-oxa-2-azaspiro[2.5]octane, (3R-cis)-; 1-Oxa-2-azaspiro[2.5]octane, 2-acetyl-5-methyl-, (3R,5S)-rel-; (3R,5S)-2-Acetyl-5-methyl-1-oxa-2-azaspiro[2.5]octane; Spirocyclic oxazolidine derivative; Chiral spiro[2.5]octane intermediate.
EINECS	Contact for details

Quality Control

Every batch of 1-Oxa-2-Azaspiro[2.5]Octane, 2-Acetyl-5-Methyl-, (3R-Cis)- (9Ci) is produced and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, and chiral analysis to ensure identity, purity, and enantiomeric excess meet exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.