Description

5'-O-DMT-5-Methyluridine is a key protected nucleoside derivative, essential for the controlled synthesis of oligonucleotides. This compound serves as a critical building block in the production of modified DNA and RNA sequences, enabling advanced research and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions focused on antisense technology, siRNA, and diagnostic probe development.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor in solid-phase synthesis for introducing 5-methyluridine modifications.
• Antisense & siRNA Therapeutics: Used to create modified oligonucleotides with enhanced stability and target specificity for gene silencing applications.
• Diagnostic Probe Development: Employed in the manufacture of labeled probes for genetic testing and molecular diagnostics.
• Structural Biology Studies: Serves as a substrate for studying nucleic acid structure, function, and protein-nucleic acid interactions.
• Pharmaceutical Intermediate: A high-purity intermediate in the synthesis of novel nucleoside-based antiviral or anticancer drug candidates.

Basic Information

Product Name	5'-O-DMT-5-Methyluridine
CAS No.	138239-62-0
Molecular Formula	C31H32N2O7
Molecular Weight	544.60 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-5-methyluridine; 5-Methyl-5'-O-DMT-uridine; 1-[(2R,3R,4R,5R)-3,4-Bis(benzyloxy)-5-[(4-methoxyphenyl)diphenylmethoxy]oxolan-2-yl]-5-methylpyrimidine-2,4-dione; DMT-5-Me-Uridine; 5-Methyl-2'-deoxyuridine 5'-O-DMT derivative; 5'-O-Dimethoxytrityl-5-methyluridine
EINECS	Contact for details

Quality Control

Our 5'-O-DMT-5-Methyluridine is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical and biotechnology customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in common organic solvents (e.g., Acetonitrile, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.