Description

(8A,9R)-Cinchonan-9-Ol Mono[[(S)-[(1R)-2-Methyl-1-(1-Oxopropoxy)Propoxy](4-Phenylbutyl)Phosphinyl]Acetate] is a sophisticated chiral organophosphorus derivative of cinchona alkaloid, designed for high-performance asymmetric synthesis. This compound matters as a highly selective catalyst or chiral auxiliary, enabling the production of enantiomerically pure intermediates critical for modern pharmaceuticals. It is primarily needed by research institutions and fine chemical manufacturers engaged in developing advanced active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Asymmetric Catalysis: As a chiral ligand or catalyst in transition metal-catalyzed reactions such as hydrogenation, hydroformylation, and conjugate addition.
• Pharmaceutical Intermediate Synthesis: For the enantioselective construction of complex molecular scaffolds in API development.
• Chiral Resolution: Employed in the separation of racemic mixtures to isolate desired enantiomers.
• Agrochemical Research: In the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: As a building block for chiral polymers or liquid crystals with specific optical properties.
• Academic & Process Chemistry: A valuable tool for methodological development and scale-up studies in synthetic organic chemistry.

Basic Information

Item	Detail
Product Name	(8A,9R)-Cinchonan-9-Ol Mono[[(S)-[(1R)-2-Methyl-1-(1-Oxopropoxy)Propoxy](4-Phenylbutyl)Phosphinyl]Acetate]
CAS No.	137590-32-0
Molecular Formula	C36H48N2O6P
Molecular Weight	644.75 g/mol
Synonyms	Mono[[(S)-[(1R)-2-Methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetate] of (8α,9R)-Cinchonan-9-ol; Cinchona Alkaloid Phosphinite Ester Derivative; (8α,9R)-9-Hydroxycinchonan Mono(4-phenylbutyl)phosphinylacetate Ester; Chiral Cinchona Phosphinite; Asymmetric Catalyst 137590-32-0
EINECS	Contact for details

Quality Control

Our high-purity chiral chemicals are manufactured under strict quality management systems. Each batch undergoes comprehensive analysis including HPLC for chiral purity and assay, NMR for structural confirmation, and specific tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.