Description

(+)-2,3-o-Isopropylidene-1,1,4,4-Tetra(2-Naphthyl)-D-Threitol CAS NO 137365-16-3 is a high-purity, chiral organic compound belonging to the class of atropisomeric diols. This compound matters as a sophisticated chiral ligand and building block, offering exceptional stereochemical control in asymmetric synthesis. It is primarily needed by research and development teams in the pharmaceutical and fine chemical industries for applications in catalysis and the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Asymmetric Catalysis: As a chiral ligand for transition metal catalysts in enantioselective C-C bond-forming reactions.
• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex, biologically active molecules.
• Material Science Research: A precursor for the development of chiral stationary phases (CSPs) used in chromatographic separation.
• Academic & Industrial R&D: For method development and exploration of novel asymmetric transformations in organic chemistry.
• Ligand Library Development: A component in high-throughput screening for discovering new catalytic systems.

Basic Information

Product Name	(+)-2,3-o-Isopropylidene-1,1,4,4-Tetra(2-Naphthyl)-D-Threitol
CAS No.	137365-16-3
Molecular Formula	C46H40O2
Molecular Weight	624.81 g/mol
Synonyms	(+)-TADDOL; (4R,5R)-2,2-Dimethyl-α,α,α',α'-tetra(2-naphthyl)-1,3-dioxolane-4,5-dimethanol; (R,R)-TADDOL; D-(-)-TADDOL; TADDOL Derivative; Atropisomeric Diol; Chiral Diol Ligand; 1,3-Dioxolane-4,5-dimethanol, 2,2-dimethyl-α,α,α',α'-tetra-2-naphthalenyl-, (4R,5R)-
EINECS	Contact for details

Quality Control

Our (+)-2,3-o-Isopropylidene-1,1,4,4-Tetra(2-Naphthyl)-D-Threitol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure consistent high performance in sensitive asymmetric applications. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged manipulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.