Description

trans-Tetrahydrofuran-3,4-Diamine Dihydrochloride is a high-purity, versatile chiral diamine building block offered as a stable dihydrochloride salt. This compound is critical for the synthesis of complex molecules, particularly in pharmaceutical research and development, where its rigid, functionalized structure provides a key scaffold. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Peptidomimetic Chemistry: The furanoid scaffold mimics peptide backbones, making it valuable for designing and synthesizing peptidomimetics and protease inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced, chiral agrochemicals such as herbicides and fungicides.
• Fine Chemical Building Block: Employed in custom synthesis and the manufacture of specialty chemicals requiring a rigid, bicyclic diamine structure.
• Academic & Industrial R&D: Essential for exploratory chemistry in academic institutions and corporate R&D departments focusing on heterocyclic and medicinal chemistry.

Basic Information

Product Name	trans-Tetrahydrofuran-3,4-Diamine Dihydrochloride
CAS No.	137279-45-9
Molecular Formula	C4H10N2O · 2HCl
Molecular Weight	187.07 g/mol
Synonyms	(3R,4R)-3,4-Diaminotetrahydrofuran Dihydrochloride; (3S,4S)-3,4-Diaminotetrahydrofuran Dihydrochloride; trans-3,4-Diaminotetrahydrofuran Dihydrochloride; 3,4-Diaminotetrahydrofuran Dihydrochloride (trans-); Tetrahydro-3,4-furandiamine Dihydrochloride (trans-); THF-3,4-diamine Dihydrochloride; 3,4-Diaminofuranidine Dihydrochloride; Furan-3,4-diyldiamine Dihydrochloride
EINECS	Contact for details

Quality Control

Our trans-Tetrahydrofuran-3,4-Diamine Dihydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.