Description

o-Cyclobutyl-Hydroxylamine Hydrochloride CAS NO 137270-23-6 is a versatile and highly functionalized organic building block, primarily used as a key intermediate in advanced pharmaceutical synthesis. Its value lies in the reactive hydroxylamine moiety, which is instrumental in constructing complex molecular architectures, particularly heterocycles and chiral amines. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, reliable intermediates for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging the cyclobutyl ring for unique biological activity.
• Chiral Auxiliary & Ligand Preparation: Serves as a starting material for the synthesis of chiral hydroxylamine derivatives used in asymmetric catalysis.
• Peptidomimetic & PROTAC® Development: The hydroxylamine group is valuable for constructing peptide bond isosteres and linkers in targeted protein degradation platforms.
• Material Science Research: Investigated as a monomer or functionalizing agent for specialty polymers with tailored properties.
• Academic & R&D Laboratories: Employed in methodological studies and the discovery of new organic transformations involving N-O bonds.

Basic Information

Product Name	o-Cyclobutyl-Hydroxylamine Hydrochloride
CAS No.	137270-23-6
Molecular Formula	C4H9NO • HCl
Molecular Weight	123.58 g/mol
Synonyms	N-(Cyclobutyl)hydroxylamine hydrochloride; Cyclobutylhydroxylamine HCl; O-Cyclobutylhydroxylamine hydrochloride; Hydroxylamine, N-cyclobutyl-, hydrochloride; 1-Cyclobutylhydroxylamine hydrochloride; N-Hydroxycyclobutanamine hydrochloride; (Cyclobutylamino)oxonium chloride
EINECS	Contact for details

Quality Control

Our o-Cyclobutyl-Hydroxylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.