Description

1,4,7,10-Tetraazacyclododecane-1-Acetic Acid,1,1-Dimethylethyl Ester is a key protected intermediate in the synthesis of sophisticated macrocyclic chelating agents. This compound is critically important for researchers and manufacturers developing advanced contrast agents for medical imaging and targeted radiopharmaceuticals. It is primarily utilized in pharmaceutical R&D and fine chemical synthesis, where high-purity building blocks are essential for creating complex molecular architectures with precise metal-binding properties.

Application

• Pharmaceutical Intermediate: A crucial precursor for synthesizing DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and its derivatives, which are foundational chelators in medicine.
• Contrast Agent Development: Used in the research and production of gadolinium-based contrast agents (GBCAs) for Magnetic Resonance Imaging (MRI).
• Radiopharmaceuticals: Serves as a building block for chelators that bind diagnostic (e.g., Gallium-68, Copper-64) and therapeutic (e.g., Lutetium-177, Yttrium-90) radioisotopes for PET imaging and targeted radiotherapy.
• Chemical Research: Employed in academic and industrial laboratories studying macrocyclic chemistry, coordination chemistry, and novel ligand design.
• Bioconjugation Linker: The protected carboxylic acid group allows for selective deprotection and conjugation to peptides, antibodies, or other targeting molecules.
• Catalyst Ligand Synthesis: Can be used to develop specialized ligands for catalytic applications in asymmetric synthesis.

Basic Information

Item	Detail
Product Name	1,4,7,10-Tetraazacyclododecane-1-Acetic Acid,1,1-Dimethylethyl Ester
CAS No.	137145-75-6
Molecular Formula	C16H32N4O2
Molecular Weight	312.45 g/mol
Synonyms	tert-Butyl DOTA monoamide; 1,4,7,10-Tetraazacyclododecane-1-acetic acid, 1,1-dimethylethyl ester; DOTA-tris(t-Bu ester) monoacid; Mono-tert-butyl DOTA; DOTA(tBu)3; 2-[4,7,10-Tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid; Protected DOTA monoacid; Cyclen-based chelator intermediate
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1-Acetic Acid,1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.