Description

1-(tert-Butoxycarbonyl)-2-Indolinecarboxylic Acid is a key Boc-protected indoline derivative used as a versatile building block in organic synthesis. This compound is highly valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for creating peptide-like molecules with enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides and pesticides with specific biological activity.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized as a scaffold for designing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high-purity, protected heterocyclic carboxylic acids.

Basic Information

Product Name	1-(tert-Butoxycarbonyl)-2-Indolinecarboxylic Acid
CAS No.	137088-51-8
Molecular Formula	C14H17NO4
Molecular Weight	263.29 g/mol
Synonyms	2-Indolinecarboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; Boc-2-Indolinecarboxylic Acid; 1-Boc-2-indolinecarboxylic acid; 1-N-Boc-indoline-2-carboxylic acid; tert-Butyl 2-carboxyindoline-1-carboxylate; 1-(tert-Butoxycarbonyl)indoline-2-carboxylic Acid; (1-Boc-indolin-2-yl)-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)-2-Indolinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.