Description

1,4,7,10-Tetrakis(Ethoxycarbonylmethyl)-1,4,7,10-Tetraazacyclododecane is a key functionalized macrocyclic ligand, specifically a tetraester derivative of the versatile 1,4,7,10-tetraazacyclododecane (cyclen) framework. This compound is of significant commercial importance as a crucial precursor for synthesizing advanced chelating agents and bifunctional chelators used in medical diagnostics and research. It is primarily sought by manufacturers and research institutions in the pharmaceutical, biotechnology, and specialty chemical sectors for developing contrast agents, radiopharmaceuticals, and metal-ion scavengers.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and its analogs, which are foundational chelators in medicine.
• MRI Contrast Agent Precursor: Used in the production of gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging (MRI), enhancing image clarity and diagnostic accuracy.
• Radiopharmaceutical Development: Serves as a starting material for bifunctional chelators that bind radioisotopes (e.g., 68Ga, 177Lu, 90Y) for targeted cancer therapy (theranostics) and diagnostic imaging (PET/SPECT).
• Research Chemical: Employed in academic and industrial R&D for studying coordination chemistry, developing new metal complexes, and creating sensors.
• Catalyst Ligand Synthesis: Utilized to prepare specialized ligands for homogeneous catalysis and metal separation processes.
• Bioconjugation Chemistry: The ester groups provide handles for further chemical modification, enabling conjugation to antibodies, peptides, or other biomolecules.

Basic Information

Product Name	1,4,7,10-Tetrakis(Ethoxycarbonylmethyl)-1,4,7,10-Tetraazacyclododecane
CAS No.	137076-50-7
Molecular Formula	C28H52N4O8
Molecular Weight	572.74 g/mol
Synonyms	1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid tetraethyl ester; DOTA-tetraethyl ester; Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane; Cyclen-tetraacetic acid tetraethyl ester; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetraethyl ester; DOTA tetraethyl ester; Tetraethyl DOTA; 1,4,7,10-Tetrakis(carbethoxymethyl)-1,4,7,10-tetraazacyclododecane
EINECS	Contact for details

Quality Control

Our production of 1,4,7,10-Tetrakis(Ethoxycarbonylmethyl)-1,4,7,10-Tetraazacyclododecane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, which is critical for downstream pharmaceutical synthesis. All materials undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.