Description

3A[n-(N'',N''-Dimethylaminoethane)-Carbamoyl]Cholesterol is a specialized cholesterol derivative functionalized with a dimethylaminoethyl carbamoyl group. This compound is significant as a key synthetic intermediate and a cationic lipid component used in the formulation of advanced delivery systems. It is primarily required by research institutions and pharmaceutical developers working on gene therapy, drug delivery, and lipid nanoparticle (LNP) technology.

Application

• Lipid Nanoparticle (LNP) Formulation: As a cationic or ionizable lipid component for the encapsulation and delivery of nucleic acids (mRNA, siRNA, DNA).
• Gene Therapy Research: A critical building block in the development of non-viral vectors for transfection and gene editing applications.
• Drug Delivery Systems: Used to create liposomes and other nanocarriers for targeted and sustained release of therapeutic agents.
• Bioconjugation & Probe Development: Serves as a cholesterol anchor for labeling cell membranes or creating biomolecular probes.
• Biomaterials & Surface Modification: Employed to modify surfaces with bioactive lipid layers for cell culture and diagnostic devices.
• Pharmaceutical Intermediate: A high-purity synthetic intermediate in the production of more complex bioactive molecules.

Basic Information

Product Name	3A[n-(N'',N''-Dimethylaminoethane)-Carbamoyl]Cholesterol
CAS No.	137056-72-5
Molecular Formula	C32H56N2O2
Molecular Weight	500.81 g/mol
Synonyms	3α-[N-(N',N'-Dimethylaminoethyl)carbamoyl]cholesterol; 3α-[2-(Dimethylamino)ethylcarbamoyl]cholesterol; Cholest-5-en-3β-ol, 3-[2-(dimethylamino)ethyl]carbamate (3α); DC-Cholesterol; DC-Chol; Dimethylaminoethane-carbamoyl Cholesterol; Cationic Cholesterol Derivative
EINECS	Contact for details

Quality Control

Our 3A[n-(N'',N''-Dimethylaminoethane)-Carbamoyl]Cholesterol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.