Description

Ecgonine Methyl Ester (D3) is a deuterated analog of the cocaine metabolite ecgonine methyl ester, specifically labeled with three deuterium atoms. This compound is of significant value as a high-purity internal standard for precise quantitative analysis in forensic, clinical, and pharmacological research. It is primarily required by analytical laboratories and research institutions conducting LC-MS/MS or GC-MS studies on cocaine and its metabolites to ensure accurate calibration and reliable results.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical deuterated internal standard for the quantification of cocaine and ecgonine methyl ester in biological matrices via LC-MS/MS or GC-MS.
• Forensic Toxicology: Used in the analysis of urine, blood, and hair samples for legal and workplace drug testing programs.
• Clinical Research: Enables accurate pharmacokinetic and metabolic studies of cocaine in controlled clinical settings.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of related substances in pharmaceutical development.
• Reference Material: Acts as a certified reference material (CRM) for method development and validation in analytical chemistry.
• Metabolite Studies: Facilitates research into the metabolic pathways and stability of cocaine derivatives.

Basic Information

Product Name	Ecgonine Methyl Ester (D3)
CAS No.	136765-34-9
Molecular Formula	C10H14D3NO4
Molecular Weight	203.24 g/mol (for D3 isotopologue)
Synonyms	(-)-Ecgonine Methyl Ester-d3; Methylecgonine-d3; 2-Carbomethoxy-3-tropinone-d3; Benzoylecgonine Methyl Ester Impurity D3; Methyl (1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate-d3; Cocaine Metabolite Standard-d3; EME-d3; Contact for EINECS details.

Quality Control

Our Ecgonine Methyl Ester (D3) is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and impurity profiles. We ensure compliance with relevant standards for reference materials, and stability data is maintained to support product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.