Description

1,3-Dioxolane-4-Butanol, .Alpha.-Butyl-.Beta.-Methoxy-2,2-Dimethyl-.Delta.-(Phenylmethoxy)-, 4R-4R*(.Alpha.R*,.Beta.R*,.Delta.S*)- is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its complex, multi-functional structure makes it a valuable precursor for constructing sophisticated molecular architectures with precise spatial orientation. This compound is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for applications requiring high stereochemical fidelity, such as in the synthesis of active pharmaceutical ingredients (APIs) and complex natural products.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly for candidates with complex stereochemical requirements.
• Asymmetric Synthesis: Employed as a sophisticated building block in catalytic asymmetric reactions to introduce multiple chiral centers with high enantiomeric excess.
• Natural Product Synthesis: Used in the total synthesis of complex natural products where its specific dioxolane and methoxy-substituted butanol framework is a structural motif.
• Ligand and Catalyst Development: Serves as a precursor for the synthesis of novel chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Utilized in the manufacture of high-value specialty chemicals, including flavors, fragrances, and advanced materials requiring specific stereochemistry.
• Academic and Industrial R&D: A critical reagent for methodological development in organic chemistry and for exploring new synthetic pathways in both academic and corporate research laboratories.

Basic Information

Product Name	1,3-Dioxolane-4-Butanol, .Alpha.-Butyl-.Beta.-Methoxy-2,2-Dimethyl-.Delta.-(Phenylmethoxy)-, 4R-4R*(.Alpha.R*,.Beta.R*,.Delta.S*)-
CAS No.	136759-80-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(4R,4aR,8R,8aS)-8-Butyl-4-methoxy-2,2-dimethyl-4,4a,8,8a-tetrahydro-[1,3]dioxolo[4,5-e][1,3]dioxin-6-ol, Benzyl Ether; 4R-4R*(αR*,βR*,δS*)-α-Butyl-β-methoxy-2,2-dimethyl-δ-(phenylmethoxy)-1,3-dioxolane-4-butanol; Chiral 1,3-dioxolane butanol derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high stereochemical purity. Each lot is characterized using advanced analytical techniques including Chiral HPLC and NMR spectroscopy to confirm identity, enantiomeric excess, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.