Description

1-Methyl-7-(Trifluoromethyl)-1H-Indole-2,3-Dione is a specialized heterocyclic building block characterized by its indole-2,3-dione (isatin) core substituted with a methyl group and a trifluoromethyl group. This compound matters as a versatile intermediate for synthesizing complex molecules, particularly in pharmaceutical research where the trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and binding affinity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the biological activity of the isatin scaffold.
• Material Science: Serves as a building block for organic semiconductors, dyes, and pigments due to its conjugated structure and electron-withdrawing properties.
• Chemical Biology: Employed as a probe or scaffold in the design of enzyme inhibitors and molecular probes for biochemical studies.
• Organic Synthesis: A valuable substrate for palladium-catalyzed cross-coupling reactions, nucleophilic substitutions, and cyclization reactions to construct more complex heterocycles.

Basic Information

Product Name	1-Methyl-7-(Trifluoromethyl)-1H-Indole-2,3-Dione
CAS No.	136622-67-8
Molecular Formula	C10H6F3NO2
Molecular Weight	229.16 g/mol
Synonyms	1-Methyl-7-(trifluoromethyl)isatin; 7-(Trifluoromethyl)-1-methylindoline-2,3-dione; 1-Methyl-7-trifluoromethylisatin; 1-Methyl-7-trifluoromethyl-1H-indole-2,3-dione; 7-Trifluoromethyl-1-methylisatin; Isatin, 1-methyl-7-(trifluoromethyl)-; N-Methyl-7-(trifluoromethyl)isatin
EINECS	Contact for details

Quality Control

Our 1-Methyl-7-(Trifluoromethyl)-1H-Indole-2,3-Dione is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) documenting all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.