Description

Technetium Tc 99M Tris(Dimethylglyoxime)-3-Carboxy-5-Isothiocyanatophenylboronic Acid is a sophisticated bifunctional chelating agent designed for the radiolabeling of biomolecules. This compound is critical for creating targeted radiopharmaceuticals used in diagnostic imaging, enabling precise visualization of biological processes. It is primarily utilized by research institutions, pharmaceutical developers, and radiopharmacies engaged in the advancement of molecular imaging and targeted radiotherapy.

Application

• Synthesis of Targeted Radiopharmaceuticals: Conjugation to monoclonal antibodies, peptides, or other targeting vectors for specific disease localization.
• SPECT Imaging Agent Development: Creation of novel diagnostic probes for oncology, cardiology, and neurology research.
• Pretargeting Strategies: Used in multi-step pretargeted radioimmunotherapy protocols to improve tumor-to-background ratios.
• Boron Neutron Capture Therapy (BNCT) Research: The phenylboronic acid moiety allows for potential dual-modality (diagnostic/therapeutic) applications.
• Bioconjugation Chemistry Research: Serves as a model compound for studying isothiocyanate-based linking chemistry with amines.
• Quality Control & Reference Standard: Used as a reference material in the analytical validation of finished radiopharmaceuticals.

Basic Information

Product Name	Technetium Tc 99M Tris(Dimethylglyoxime)-3-Carboxy-5-Isothiocyanatophenylboronic Acid
CAS No.	136537-22-9
Molecular Formula	C20H24BN7O8S 99mTc
Molecular Weight	Contact for details
Synonyms	Tc-99m Tricarbonyl Isothiocyanatophenylboronic Acid-DMG Complex; 99mTc(CO)3(DMG-COOH-B-ITC); Technetium-99m Labeled Boronic Acid Isothiocyanate; BATO Derivative (Boron Acid Technetium Oxime); [99mTc][Tc(CO)3(DMG-3-C-5-I-BA)]+; 3-Carboxy-5-isothiocyanatophenylboronic acid tris(dimethylglyoximato)technetium(I); Tc-99m-BA-ITC-DMG
EINECS	Contact for details

Quality Control

This high-purity precursor is manufactured under strict quality systems to ensure consistency for sensitive radiopharmaceutical synthesis. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing radiochemical purity, chemical purity, and specific activity where applicable. Our quality protocols are designed to meet the exacting standards of GMP-compliant radiopharmaceutical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at the recommended temperature (typically 2-8°C or as specified on the label). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere if necessary to prevent degradation. Handle in accordance with all radiation safety regulations.

Specification

Item	Specification
Appearance	Solid (Color to be specified)
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Chemical Purity (HPLC)	≥ 95%
Radiochemical Purity (ITLC/HPLC)	≥ 95% 99mTc
Specific Activity	Contact for details
Isothiocyanate Group Integrity	Assayed (by titration or HPLC)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.