Description

Heparin Disaccharide Ii-A, Sodium Salt is a well-defined, low molecular weight oligosaccharide derived from the enzymatic or chemical depolymerization of heparin. This compound serves as a critical reference standard and biochemical tool for research into heparin structure, function, and metabolism. It is essential for scientists and quality control professionals in the pharmaceutical and biotechnology sectors who require high-purity materials for analytical method development, enzymatic activity studies, and structural elucidation.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity profiling of heparin and low molecular weight heparin (LMWH) products in compliance with pharmacopeial monographs (USP, EP).
• Enzymology Research: Acts as a specific substrate or inhibitor in studies of heparinase and other glycosaminoglycan (GAG)-degrading enzymes to understand enzyme kinetics and mechanisms.
• Structural Biology: Employed in nuclear magnetic resonance (NMR) and mass spectrometry (MS) analyses to map the fine structure of heparin and heparan sulfate chains.
• Biomarker Development: Utilized in the development of diagnostic assays for detecting and quantifying specific heparin-derived disaccharides in biological samples.
• Glycobiology Studies: Serves as a key building block or probe for investigating the role of specific sulfation patterns in heparin-protein interactions, such as with antithrombin III.
• Quality Control & Method Validation: Critical for calibrating analytical instruments (e.g., HPLC, CE) and validating test methods in pharmaceutical quality control laboratories.

Basic Information

Product Name	Heparin Disaccharide Ii-A, Sodium Salt
CAS No.	136098-06-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	δUA-GlcNS,6S; 2-O-Sulfo-α-L-iduronic acid-(1→4)-2-deoxy-2-sulfoamino-6-O-sulfo-D-glucose, Sodium Salt; Heparin disaccharide II-A; IdoA(2S)-GlcNS(6S); Disaccharide Ii-A (Heparin); Sodium 4-deoxy-α-L-threo-hex-4-enopyranosyluronate-(1→4)-2-deoxy-2-sulfamido-6-O-sulfo-D-glucopyranoside; Heparin-derived disaccharide II-A
EINECS	Contact for details

Quality Control

Our Heparin Disaccharide Ii-A, Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at low temperature. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (on dried basis)
Water Content (KF)	≤ 5.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.