Description

H-Sar-Otbu Hcl is a protected amino acid derivative, specifically the hydrochloride salt of N-(tert-Butoxycarbonyl)-Sarcosine. This high-purity building block is critical for the controlled synthesis of complex peptides and peptidomimetics, where it introduces the unique N-methylglycine (sarcosine) moiety. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Pharmaceutical Intermediate: Key building block in the solid-phase and solution-phase synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to incorporate sarcosine residues into peptidomimetic structures to enhance metabolic stability, bioavailability, and binding affinity.
• Bioconjugation & Probe Development: Serves as a spacer or linker component in the creation of labeled peptides for diagnostic assays and imaging.
• Academic & R&D Laboratories: Fundamental reagent for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.
• Custom Peptide Synthesis: A standard, high-quality starting material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide services.

Basic Information

Product Name	H-Sar-Otbu Hcl
CAS No.	136088-69-2
Molecular Formula	C8H16ClNO4
Molecular Weight	225.67 g/mol
Synonyms	Sarcosine, N-[(1,1-Dimethylethoxy)carbonyl]-, hydrochloride; N-(tert-Butoxycarbonyl)sarcosine hydrochloride; Boc-Sarcosine-OH · HCl; Boc-Sar-OH · HCl; N-Boc-sarcosine hydrochloride; (2-{[(tert-Butoxy)carbonyl](methyl)amino}acetic acid) hydrochloride; N-Methyl-N-(tert-butoxycarbonyl)glycine hydrochloride
EINECS	Contact for details

Quality Control

Our H-Sar-Otbu Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for water content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.