Description

5-Chlorothiokynurenic Acid is a specialized heterocyclic organic compound of significant interest in advanced chemical research and development. This compound serves as a critical synthetic intermediate and a valuable pharmacological tool for investigating excitatory amino acid receptors and related neurological pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers engaged in the development of novel neuroactive agents and biochemical probes.

Application

• Pharmaceutical Research & Development: Acts as a key intermediate in the synthesis of novel compounds targeting the glycine site of the NMDA receptor.
• Neuroscience Tool Compound: Used as a selective research chemical to study the role of kynurenic acid pathways and excitotoxicity in neurological disorders.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies to develop potential neuroprotective agents.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening assays for receptor binding studies.
• Academic Research: Utilized in university and institutional labs for fundamental research into glutamate receptor function and modulation.
• Fine Chemical Synthesis: A precursor for the preparation of more complex, functionally modified thiokynurenic acid derivatives.

Basic Information

Product Name	5-Chlorothiokynurenic Acid
CAS No.	136036-87-8
Molecular Formula	C10H6ClNO2S
Molecular Weight	239.68 g/mol
Synonyms	5-Chloro-4-hydroxy-2-mercaptoquinoline-3-carboxylic acid; 5-Chloro-4-hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylic acid; 5-Chloro-4-hydroxy-2-thioxo-1,2-dihydro-3-quinolinecarboxylic acid; 5-Chloro-4-hydroxy-2-mercapto-3-quinolinecarboxylic acid; 5-Chloro-4-hydroxy-2-sulfanylquinoline-3-carboxylic acid; 5-Chloro-4-hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate (acid form)
EINECS	Contact for details

Quality Control

Our 5-Chlorothiokynurenic Acid is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.