Description

Boc-(2-Aminophenyl)Acetic Acid CAS NO 135807-51-1 is a protected amino acid derivative, specifically an ortho-aminophenylacetic acid with a tert-butoxycarbonyl (Boc) protecting group on the amine. This compound is a crucial chiral building block and intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists for constructing peptidomimetics, active pharmaceutical ingredients (APIs), and other bioactive compounds where the ortho-amino phenylacetic acid scaffold is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in oncology, neurology, and anti-infective therapeutic areas.
• Peptidomimetic Synthesis: Used to incorporate non-natural amino acid residues into peptide chains to enhance stability, bioavailability, and biological activity.
• API Development: Serves as a critical building block in the research, development, and scale-up manufacturing of Active Pharmaceutical Ingredients (APIs).
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and activity-based protein profiling reagents.
• Agrochemical Research: Acts as an intermediate in the development of advanced crop protection agents and herbicides.
• Academic & Contract Research: Essential for synthetic organic chemistry research in academic institutions and contract research organizations (CROs).

Basic Information

Product Name	Boc-(2-Aminophenyl)Acetic Acid
CAS No.	135807-51-1
Molecular Formula	C₁₃H₁₇NO₄
Molecular Weight	251.28 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]-2-(2-aminophenyl)acetic acid; (2-Amino-2-(2-aminophenyl)acetic acid tert-butyl ester; N-Boc-2-amino-2-(2-aminophenyl)acetic acid; Boc-2-Abz-OH; N-(tert-Butoxycarbonyl)-2-aminophenylglycine; 2-((tert-Butoxycarbonyl)amino)-2-(2-aminophenyl)ethanoic acid; Boc-(2-Abz)-OH; (2-Aminophenyl)((tert-butoxycarbonyl)amino)acetic acid
EINECS	Contact for details

Quality Control

Our Boc-(2-Aminophenyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We adhere to cGMP guidelines where applicable to support our customers' regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.