Description

n-Dodecanoyl-4-Hydroxy-L-Proline is a high-purity, specialized proline derivative where the amino acid is acylated with a lauric acid (C12) chain. This modification imparts unique amphiphilic properties, making it a valuable building block for advanced research and formulation chemistry. It is primarily sought after by researchers and product developers in the pharmaceutical and cosmetic industries. Its structure is designed to enhance bioavailability and modify the physicochemical characteristics of parent compounds.

Application

• Pharmaceutical Intermediates: Serves as a key synthon in the development of novel Active Pharmaceutical Ingredients (APIs), particularly for prodrug strategies and peptide mimetics.
• Cosmetic Actives & Delivery Systems: Used in the formulation of advanced skincare products for its potential skin-conditioning properties and role in enhancing the penetration of other active ingredients.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development for specialized amino acid analysis.
• Surfactant & Micelle Studies: Employed in academic and industrial research to study the behavior of amino acid-based surfactants due to its defined hydrophobic tail.
• Peptide Chemistry: Used as a modified amino acid residue in solid-phase peptide synthesis (SPPS) to introduce lipophilicity and alter peptide conformation.

Basic Information

Product Name	n-Dodecanoyl-4-Hydroxy-L-Proline
CAS No.	135777-18-3
Molecular Formula	C₁₇H₃₁NO₄
Molecular Weight	313.43 g/mol
Synonyms	L-Proline, 4-hydroxy-, 1-dodecanoyl-; 4-Hydroxy-L-proline dodecanoyl ester; Dodecanoyl-4-hydroxyproline; Lauryl-4-hydroxy-L-proline; N-Lauroyl-4-hydroxy-L-proline; (2S,4R)-1-(Dodecanoyl)-4-hydroxypyrrolidine-2-carboxylic acid; N-Dodecanoyl-trans-4-hydroxy-L-proline; 135777-18-3
EINECS	Contact for details

Quality Control

We supply n-Dodecanoyl-4-Hydroxy-L-Proline to high-purity standards suitable for research and development. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. Our quality system supports compliance with cGMP and ISO standards for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.