Description

1,3-Dioxane,2,4,6-Trimethyl-2-(1-Methylethyl)-,[4R-(2Alpha,4Alpha,6Bta)]-(9Ci) is a high-purity, stereochemically defined cyclic acetal compound. This chemical is valued for its role as a versatile building block and protecting group in sophisticated organic synthesis, particularly in the pharmaceutical and fine chemical sectors. It is primarily sought after by R&D chemists and process development scientists for the synthesis of complex molecules where precise stereochemistry and functional group manipulation are critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for complex, stereospecific drug candidates.
• Fine Chemical Synthesis: Used as a specialized reagent or protecting group in the production of agrochemicals, flavors, fragrances, and advanced materials.
• Academic & Industrial Research: Serves as a valuable substrate in methodological development for new catalytic reactions and asymmetric synthesis protocols.
• Process Chemistry: Employed in scale-up and optimization studies for the development of efficient and cost-effective manufacturing routes.

Basic Information

Product Name	1,3-Dioxane,2,4,6-Trimethyl-2-(1-Methylethyl)-,[4R-(2Alpha,4Alpha,6Bta)]-(9Ci)
CAS No.	135637-12-6
Molecular Formula	C10H20O2
Molecular Weight	172.26 g/mol
Synonyms	(4R,6S)-2,2,4,6-Tetramethyl-1,3-dioxane; (2R,4S,6R)-2,4,6-Trimethyl-2-isopropyl-1,3-dioxane; 2-Isopropyl-2,4,6-trimethyl-1,3-dioxane; (4R-cis)-2,2,4,6-Tetramethyl-1,3-dioxane; Tetramethyl-1,3-dioxane derivative; Chiral 1,3-dioxane; Stereoisomeric 1,3-dioxane acetal.
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through advanced analytical techniques including chiral HPLC, GC, and NMR to confirm identity, enantiomeric excess, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.