Description

3-(Boc-Amino)-4-Hydroxybenzoic Acid CAS NO 135322-01-9 is a protected amino acid derivative, specifically a tert-butoxycarbonyl (Boc)-protected intermediate, essential for advanced organic synthesis. This compound is a critical building block for the controlled introduction of amino-hydroxybenzoic acid motifs, offering a versatile handle for peptide coupling and further functionalization. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development of novel active pharmaceutical ingredients (APIs), complex peptides, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), particularly those requiring protected amino acid functionalities.
• Peptide Synthesis: Serves as a crucial Boc-protected building block for solid-phase and solution-phase peptide synthesis, enabling the construction of specific peptide sequences.
• Chemical Research & Development: Used in academic and industrial R&D labs for exploring new synthetic pathways and creating novel chemical entities for biological screening.
• Ligand and Conjugate Preparation: Employed in the preparation of specialized ligands, bioconjugates, and molecular probes for diagnostic and biochemical applications.
• Fine Chemical Production: Acts as a high-value intermediate in the multi-step synthesis of advanced fine chemicals and specialty materials.

Basic Information

Product Name	3-(Boc-Amino)-4-Hydroxybenzoic Acid
CAS No.	135322-01-9
Molecular Formula	C₁₂H₁₅NO₅
Molecular Weight	253.25 g/mol
Synonyms	4-Hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]benzoic acid; 3-[(tert-Butoxycarbonyl)amino]-4-hydroxybenzoic acid; Boc-3-Amino-4-hydroxybenzoic acid; N-Boc-3-amino-4-hydroxybenzoic acid; tert-Butyl (3-carboxy-4-hydroxyphenyl)carbamate; 3-(tert-Butoxycarbonylamino)-4-hydroxybenzoic acid; 3-(Boc-amino)-4-hydroxybenzoic acid
EINECS	Contact for details

Quality Control

Our 3-(Boc-Amino)-4-Hydroxybenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.