Description

2-((2R,3R,5R,6R,7R,8R)-Cuban-1-Yl)Acetic Acid is a high-purity, stereochemically defined derivative of the rigid cubane scaffold, prized for its unique three-dimensional structure and functional handle. This compound is critical for advanced research and development in medicinal chemistry, where it serves as a non-classical bioisostere to modulate the physicochemical properties and metabolic stability of lead molecules. It is primarily sought by pharmaceutical R&D teams, agrochemical innovators, and academic researchers working on novel materials and high-energy compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of novel drug candidates, particularly in areas targeting central nervous system (CNS) disorders and metabolic diseases.
• Medicinal Chemistry Research: Used as a rigid, three-dimensional scaffold to explore structure-activity relationships (SAR) and improve the potency and selectivity of bioactive molecules.
• Agrochemical Development: Employed in the design of new-generation pesticides and herbicides, leveraging the cubane core's stability and unique spatial geometry.
• Advanced Materials Science: Investigated as a precursor for high-density, high-stability polymers and energetic materials due to the inherent strain and symmetry of the cubane structure.
• Chemical Biology Probes: Utilized to create molecular probes for studying protein-ligand interactions and enzyme mechanisms, benefiting from its distinct shape and derivatizable acetic acid group.
• Academic & Institutional R&D: A valuable reagent for synthetic methodology development and fundamental studies in stereochemistry and strained hydrocarbon chemistry.

Basic Information

Product Name	2-((2R,3R,5R,6R,7R,8R)-Cuban-1-Yl)Acetic Acid
CAS No.	135191-75-2
Molecular Formula	C12H12O2
Molecular Weight	188.22 g/mol
Synonyms	(1R,2R,4R,5R,7R,8R)-Cubane-1-acetic Acid; (1R,2R,4R,5R,7R,8R)-1-Cubanylacetic Acid; (R,R,R,R,R,R)-Cubane-1-acetic Acid; 1-Cubanylacetic Acid (stereoisomer); Cubane-1-acetic Acid Derivative; 2-(Cuban-1-yl)acetic Acid (all-R enantiomer); 1-Cubanecarboxylic Acid, Methylenecarboxy Derivative; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Every batch of 2-((2R,3R,5R,6R,7R,8R)-Cuban-1-Yl)Acetic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and development. Specifications typically cover chiral purity, chemical purity, and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from oxidizing agents and strong bases. Due to its sensitivity, prolonged exposure to air and light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.