Description

Boc-Metyr(Me)-Oh Dcha CAS NO 135103-27-4 is a protected amino acid derivative, specifically the dicyclohexylamine (DCHA) salt of Boc-O-methyl-L-tyrosine. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering enhanced solubility and handling properties for advanced pharmaceutical research. It is primarily utilized by research scientists and process chemists in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents, including peptide-based drugs and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of modified tyrosine residues into peptide chains.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and small proteins where solubility of intermediates is a concern.
• Pharmaceutical Research & Development: Serves as a crucial building block in the discovery and development of peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Process Chemistry & Scale-Up: Employed in the development of robust and scalable synthetic routes for Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Bioconjugation & Labeling: The protected phenolic group allows for selective deprotection and subsequent functionalization for creating labeled peptides or antibody-drug conjugates (ADCs).
• Academic Research: Used in universities and research institutes for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	Boc-Metyr(Me)-Oh Dcha
CAS No.	135103-27-4
Molecular Formula	C27H44N2O5
Molecular Weight	476.65 g/mol
Synonyms	Boc-O-methyl-L-tyrosine dicyclohexylamine salt; (2S)-3-(4-Methoxyphenyl)-2-[(tert-butoxycarbonyl)amino]propanoic acid compound with dicyclohexylamine; N-(tert-Butoxycarbonyl)-O-methyl-L-tyrosine DCHA salt; Boc-Tyr(Me)-OH·DCHA; Boc-L-Tyrosine(Me)-OH DCHA salt; tert-Butyloxycarbonyl-O-methyl-L-tyrosine dicyclohexylammonium salt; Boc-O-Me-L-Tyr-OH·DCHA
EINECS	Contact for details

Quality Control

Our Boc-Metyr(Me)-Oh Dcha is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for demanding research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards, and our quality systems support the requirements for materials used in cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in methanol)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.