Description

5,7-Dichlorothiokynurenic Acid is a high-purity, specialized organic compound of significant interest in advanced chemical research and development. This compound serves as a critical synthetic intermediate and a potent, selective pharmacological tool for investigating excitatory amino acid receptors, particularly the glycine site of the NMDA receptor. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and conducting detailed neuropharmacological studies.

Application

• Pharmaceutical Research & Development: Acts as a key building block in the synthesis of novel NMDA receptor antagonists and other central nervous system (CNS) targeted compounds.
• Neuroscience Research: Used as a selective research chemical to study the glycine co-agonist site of the NMDA receptor complex, aiding in the understanding of neurological pathways and disorders.
• Biochemical Assay Development: Employed as a reference standard or active agent in high-throughput screening (HTS) assays to identify new drug candidates targeting glutamate receptors.
• Fine Chemical Synthesis: Serves as a versatile intermediate for the preparation of more complex thiokynurenic acid derivatives and heterocyclic compounds.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry, neuropharmacology, and organic synthesis methodologies.

Basic Information

Product Name	5,7-Dichlorothiokynuric Acid
CAS No.	135025-62-6
Molecular Formula	C10H5Cl2NO2S
Molecular Weight	274.12 g/mol
Synonyms	5,7-Dichloro-4-hydroxy-2-mercaptoquinoline-3-carboxylic acid; 5,7-Dichloro-4-hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylic acid; Thiokynurenic acid, 5,7-dichloro-; 5,7-Dichloro-4-hydroxy-2-thioxo-1,2-dihydro-3-quinolinecarboxylic acid; L-701,324 (common research code)
EINECS	Contact for details

Quality Control

Our 5,7-Dichlorothiokynurenic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥95% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to cGMP principles for research-grade materials, and specifications can be tailored to meet the rigorous demands of preclinical and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.