Description

Bastadin 12 is a brominated tyrosine-derived alkaloid, a member of the bastadin family of marine natural products isolated from sponges. This compound is of significant interest in biochemical and pharmacological research due to its potent and selective activity as an inhibitor of the IP3 receptor-mediated Ca2+ release channel. Researchers and developers in the life sciences sector utilize Bastadin 12 CAS NO 134981-78-5 as a critical tool compound for studying calcium signaling pathways and related cellular processes.

Application

• Biochemical Research: A key pharmacological tool for investigating intracellular calcium (Ca2+) signaling and store-operated calcium entry (SOCE) mechanisms.
• Cell Biology Studies: Used to probe the function of inositol 1,4,5-trisphosphate (IP3) receptors in various cell types and disease models.
• Neuroscience Research: Applied in studies of neuronal calcium homeostasis, synaptic plasticity, and neurodegenerative conditions.
• Cardiovascular Research: Employed to understand calcium regulation in cardiac and smooth muscle cells.
• Drug Discovery: Serves as a reference compound and starting point for developing novel modulators of calcium signaling for therapeutic applications.
• Academic & Institutional Labs: Essential for fundamental research in university and government research institutions worldwide.

Basic Information

Product Name	Bastadin 12
CAS No.	134981-78-5
Molecular Formula	C34H30Br4N4O8
Molecular Weight	933.15 g/mol
Synonyms	Bastadin-12; 5,5'-[1,12-Dodecanediylbis(iminocarbonyl)]bis[3-bromo-4-hydroxybenzeneacetic acid] 2,4(1H,3H)-dione; 5,5'-[1,12-Dodecanediylbis(iminocarbonyl)]bis[3-bromo-4-hydroxybenzeneacetic acid] 2,4-dihydro-2,4-dioxo-; IP3 Receptor Inhibitor Bastadin 12; Marine Brominated Alkaloid
EINECS	Contact for details

Quality Control

Our Bastadin 12 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is characterized using advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substance profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and ensure long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.