Description

D-Serine, 2-Methyl-, Methyl Ester, Hydrochloride (1:1) is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical chiral building block and intermediate for the development of novel bioactive molecules, including peptide mimetics and enzyme inhibitors. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex, stereochemically defined compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for neurological and metabolic targets.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to introduce modified serine residues into peptide chains or to create non-peptide analogs with enhanced stability and bioavailability.
• Chemical Biology & Proteomics Research: Employed as a tool compound or precursor in the study of enzyme mechanisms, protein-protein interactions, and metabolic pathways.
• Asymmetric Synthesis Catalyst/ Ligand Precursor: Its chiral structure makes it a valuable starting material for synthesizing specialized ligands and catalysts used in enantioselective transformations.
• Agrochemical Research: Potential intermediate in the development of novel, chiral herbicides or plant growth regulators.
• Academic & Industrial R&D: Serves as a standard or reference material in analytical method development and purity assessment for related chemical series.

Basic Information

Product Name	D-Serine, 2-Methyl-, Methyl Ester, Hydrochloride (1:1)
CAS No.	134899-86-8
Molecular Formula	C5H12ClNO3
Molecular Weight	169.61 g/mol
Synonyms	Methyl (2R)-2-amino-2-methyl-3-hydroxypropanoate hydrochloride; D-2-Methylserine methyl ester hydrochloride; (R)-2-Amino-2-methyl-3-hydroxypropionic acid methyl ester hydrochloride; Methyl D-2-methylserinate hydrochloride; D-α-Methylserine methyl ester HCl; (2R)-2-Amino-2-methyl-3-hydroxypropanoic acid methyl ester hydrochloride; D-Threonine methyl ester hydrochloride (isomeric form); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our D-Serine, 2-Methyl-, Methyl Ester, Hydrochloride (1:1) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC or titration), and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be aligned with client requirements for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation or clumping. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.