Description

Exo-3-Cbz-3-Azabicyclo[3.1.0]Hexane-6-Methanol is a sophisticated, nitrogen-containing bicyclic building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within the CNS and antiviral therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities.
• Process Chemistry: Serves as a starting material or advanced intermediate in the development of scalable, GMP-compliant synthetic routes for active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a building block to introduce the rigid, three-dimensional azabicyclo[3.1.0]hexane scaffold with defined stereochemistry into target molecules.
• Protease Inhibitor Development: Potential application in the synthesis of inhibitors targeting specific enzymes.
• Chemical Biology: Can be employed as a molecular probe or linker in the study of biological systems and target identification.

Basic Information

Product Name	Exo-3-Cbz-3-Azabicyclo[3.1.0]Hexane-6-Methanol
CAS No.	134575-14-7
Molecular Formula	C15H19NO3
Molecular Weight	261.32 g/mol
Synonyms	6-(Hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester (exo-); exo-3-Carbobenzoxy-3-azabicyclo[3.1.0]hexane-6-methanol; exo-(6-Hydroxymethyl-3-azabicyclo[3.1.0]hex-3-yl)-carbamic acid benzyl ester; exo-3-Cbz-3-azabicyclo[3.1.0]hexane-6-methanol; N-Cbz-3-azabicyclo[3.1.0]hexane-6-methanol (exo-); Benzyl (1S,5R,6R)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate; exo-N-Cbz-3-aza-6-hydroxymethylbicyclo[3.1.0]hexane
EINECS	Contact for details

Quality Control

Our Exo-3-Cbz-3-Azabicyclo[3.1.0]Hexane-6-Methanol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee (exo- isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.