Description

S-(2-Thiopyridyl)Cysteine Hydrazide is a specialized heterocyclic organic compound featuring a unique cysteine-derived hydrazide moiety linked to a 2-thiopyridyl group. This molecular architecture makes it a valuable reagent for the selective modification and detection of carbonyl groups, particularly in complex biochemical systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for protein analysis, cross-linking, and the development of sensitive assay kits.

Application

• Bioconjugation & Protein Labeling: Acts as a key reagent for the site-specific modification of proteins and antibodies via carbonyl groups, essential for creating antibody-drug conjugates (ADCs) and diagnostic probes.
• Analytical Chemistry & Assay Development: Used in the derivatization of aldehydes and ketones for their sensitive detection and quantification via HPLC, LC-MS, or fluorescence.
• Cross-linking Agent: Serves as a homobifunctional cross-linker for studying protein-protein interactions and stabilizing macromolecular complexes.
• Protecting Group Chemistry: Employed in peptide synthesis and organic synthesis as a protective group for thiols or as a precursor for other functionalized molecules.
• Diagnostic Kit Component: Incorporated into enzymatic and immunoassay kits for the detection of specific biomarkers that involve carbonyl intermediates.
• Research Chemical: A critical tool in academic and industrial R&D for exploring new biochemical pathways, enzyme mechanisms, and metabolic profiling.

Basic Information

Product Name	S-(2-Thiopyridyl)Cysteine Hydrazide
CAS No.	134555-14-9
Molecular Formula	C8H11N3OS2
Molecular Weight	229.32 g/mol
Synonyms	2-Thiopyridyl Cysteine Hydrazide; S-(2-Pyridylthio)cysteine hydrazide; Cysteine hydrazide, S-(2-pyridinylthio)-; N-[(2-Pyridinylthio)methyl]glycine hydrazide; TPCH; 2-Pyridylthio Cysteine Hydrazide; S-2-Pyridylcysteine hydrazide; (2-Pyridyldithio)cysteine hydrazide
EINECS	Contact for details

Quality Control

Our S-(2-Thiopyridyl)Cysteine Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.