Description

2-Maleimidoethylamine Hcl is a heterobifunctional crosslinking reagent featuring a maleimide group and a primary amine, activated as its hydrochloride salt. This compound is essential for creating stable, site-specific conjugates between amine-containing molecules and thiol groups under mild conditions. It is a critical building block for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and protein/peptide chemistry.

Application

• Bioconjugation and ADC Linker Chemistry: A key reagent for constructing antibody-drug conjugates (ADCs) and other protein-drug conjugates by linking amine-containing payloads to cysteine residues on antibodies or proteins.
• Protein and Peptide Modification: Used to introduce maleimide functional groups onto peptides, proteins, or other amine-containing biomolecules for subsequent thiol coupling.
• Surface Functionalization: Employed to modify amine-coated surfaces (e.g., beads, chips, slides) with maleimide groups to immobilize thiolated ligands, DNA, or proteins.
• Polymer Chemistry: Serves as a functional monomer or crosslinker in the synthesis of smart polymers and hydrogels with responsive properties.
• Diagnostic Reagent Synthesis: Utilized in the development of enzyme conjugates, fluorescent probes, and other diagnostic reagents requiring stable, defined linkages.
• Materials Science: Facilitates the creation of novel biomaterials by crosslinking different polymeric components through amine-maleimide chemistry.

Basic Information

Product Name	2-Maleimidoethylamine Hcl
CAS No.	134272-64-3
Molecular Formula	C6H9N2O2•HCl
Molecular Weight	192.61 g/mol
Synonyms	N-(2-Aminoethyl)maleimide hydrochloride; 2-Maleimidoethanamine hydrochloride; Maleimidoethylamine HCl; N-(2-Aminoethyl)maleimide HCl; 2-(Maleimid-1-yl)ethylamine hydrochloride; EMA•HCl; 1-(2-Aminoethyl)-1H-pyrrole-2,5-dione hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Maleimidoethylamine Hcl is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.