Description

(R)-4-Carboxyphenylglycine is a high-purity, single-enantiomer chiral building block of significant importance in advanced organic synthesis. Its primary value lies in its role as a key intermediate for the development of active pharmaceutical ingredients (APIs), particularly in the creation of novel therapeutics. This compound is essential for research and manufacturing organizations in the pharmaceutical, biotechnology, and fine chemical sectors that require optically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug molecules, especially those targeting neurological and metabolic disorders.
• Peptide Mimetic Research: Used in the design and construction of peptidomimetics and constrained amino acid analogs for medicinal chemistry.
• Ligand Synthesis: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Bioconjugation Chemistry: The carboxylic acid and amino functional groups enable its use in linker chemistry for antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Employed in the development of activity-based probes and molecular tools for studying enzyme function and biological pathways.
• Fine Chemical Production: An important building block for the custom synthesis of specialty chemicals and advanced materials.

Basic Information

Item	Details
Product Name	(R)-4-Carboxyphenylglycine
CAS No.	134052-68-9
Molecular Formula	C9H9NO4
Molecular Weight	195.17 g/mol
Synonyms	(R)-2-Amino-2-(4-carboxyphenyl)acetic acid; (R)-4-Carboxy-D-phenylglycine; D-4-Carboxyphenylglycine; (R)-α-Amino-4-carboxybenzeneacetic acid; (2R)-2-Amino-2-(4-carboxyphenyl)ethanoic acid; (R)-Amino(4-carboxyphenyl)acetic acid
EINECS	Contact for details

Quality Control

Our (R)-4-Carboxyphenylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.