Description

2,5-Diazabicyclo[2.2.1]Heptane,2-(2-Pyrimidinyl)-,(1S)-(9Ci) is a high-purity, chiral bicyclic diamine derivative with significant utility in advanced organic synthesis. Its rigid, three-dimensional scaffold makes it a valuable building block for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is primarily sought by medicinal chemists and process development scientists for applications in asymmetric catalysis and as a key chiral intermediate or ligand in the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Asymmetric Catalyst Ligand: Used to develop and screen novel chiral ligands for transition metal-catalyzed asymmetric reactions, such as hydrogenations and cross-couplings.
• Agrochemical Research: Employed in the research and development of new, enantiomerically pure active ingredients for crop protection agents.
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes to study enzyme mechanisms and protein-ligand interactions.
• Material Science: Investigated as a monomer or additive for creating polymers with specific chiral or structural properties.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting research in synthetic methodology and medicinal chemistry.

Basic Information

Product Name	2,5-Diazabicyclo[2.2.1]Heptane,2-(2-Pyrimidinyl)-,(1S)-(9Ci)
CAS No.	133982-56-6
Molecular Formula	C9H12N4
Molecular Weight	176.22 g/mol
Synonyms	(1S)-2-(Pyrimidin-2-yl)-2,5-diazabicyclo[2.2.1]heptane; (1S)-2-(2-Pyrimidinyl)-2,5-diazabicyclo[2.2.1]heptane; 2,5-Diazabicyclo[2.2.1]heptane, 2-(2-pyrimidinyl)-, (1S)-; (1S)-2-(2-Pyrimidyl)-2,5-diazabicyclo[2.2.1]heptane; 2-(Pyrimidin-2-yl)-2,5-diazabicyclo[2.2.1]heptane (S-enantiomer); Chiral Pyrimidyl Diazabicycloheptane; (S)-2-(2-Pyrimidinyl)-2,5-diazabicyclo[2.2.1]heptane
EINECS	Contact for details

Quality Control

Our 2,5-Diazabicyclo[2.2.1]Heptane,2-(2-Pyrimidinyl)-,(1S)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.