Description

2'-o-Allyluridine is a chemically modified nucleoside derivative, specifically a uridine analog with an allyl group at the 2'-oxygen position. This modification is crucial for imparting unique chemical and biological properties, making it a valuable intermediate in advanced research and development. It is primarily utilized in the synthesis of oligonucleotides for therapeutic and diagnostic applications, where precise structural control is essential. This compound is of significant interest to pharmaceutical researchers and biotech companies focused on nucleic acid chemistry and drug discovery.

Application

• Oligonucleotide Synthesis: A key building block (phosphoramidite) for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense & siRNA Therapeutics: Used to create nucleoside analogs that enhance the stability, specificity, and delivery of therapeutic oligonucleotides.
• Structural Biology Studies: Employed to probe RNA structure, function, and protein-RNA interactions through site-specific modification.
• Diagnostic Probe Development: Serves as a precursor for labeled nucleotides used in fluorescence in situ hybridization (FISH) and other detection assays.
• Medicinal Chemistry Research: A versatile intermediate for exploring structure-activity relationships (SAR) in the design of novel antiviral and anticancer agents.
• Bioconjugation & Labeling: The allyl group provides a handle for further chemical functionalization via click chemistry or other coupling reactions.

Basic Information

Product Name	2'-o-Allyluridine
CAS No.	133766-24-2
Molecular Formula	C12H16N2O6
Molecular Weight	284.26 g/mol
Synonyms	2'-O-Allyluridine; 1-((2R,3R,4R,5R)-3-Allyl-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl)pyrimidine-2,4-dione; Uridine, 2'-O-allyl-; 2'-O-(2-Propenyl)uridine; Allyl 2'-uridine ether; 2'-Allyloxyuridine
EINECS	Contact for details

Quality Control

Every batch of 2'-o-Allyluridine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality protocol includes HPLC for assay and purity determination, along with comprehensive spectroscopic identification (NMR, IR, MS). A Certificate of Analysis (COA) detailing all test results is provided with each shipment, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.