Description

7-Methylbenz(A)Anthracene 3,4-Dihydrodiol 1,2-Epoxide is a highly specific and reactive polycyclic aromatic hydrocarbon (PAH) metabolite, crucial for advanced toxicological and carcinogenesis research. Its primary value lies in its role as a definitive reference standard for studying the metabolic activation pathways of PAHs and their subsequent DNA adduct formation. This compound is essential for researchers and quality control laboratories in the pharmaceutical, environmental safety, and chemical toxicology sectors who require high-purity, well-characterized materials for method validation and mechanistic studies.

Application

• Toxicological Research: Serves as a critical reference standard in studies investigating the metabolic activation and DNA-binding mechanisms of carcinogenic polycyclic aromatic hydrocarbons (PAHs).
• Biomarker Development: Used in the development and validation of analytical methods (e.g., HPLC-MS, GC-MS) for detecting and quantifying specific PAH-DNA adducts as exposure biomarkers.
• Chemical Carcinogenesis Studies: A key reagent in laboratory research to understand the structure-activity relationships of PAH derivatives and their oncogenic potential.
• Pharmaceutical Safety Assessment: Employed in impurity profiling and genotoxicity testing of drug candidates to assess potential risks from PAH-like structures.
• Environmental Analysis: Acts as a high-purity calibrant for sophisticated instrumentation used in monitoring environmental pollutants and their biologically active metabolites.
• Academic and Institutional Research: Fundamental tool for universities and government research institutes focused on cancer biology, molecular epidemiology, and organic chemistry.

Basic Information

Product Name	7-Methylbenz(A)Anthracene 3,4-Dihydrodiol 1,2-Epoxide
CAS No.	133645-02-0
Molecular Formula	C21H16O3
Molecular Weight	316.35 g/mol
Synonyms	7-Methylbenz[a]anthracene 3,4-dihydrodiol 1,2-epoxide; 7-Methyl-BA 3,4-diol-1,2-epoxide; anti-7-Methylbenz[a]anthracene-3,4-diol-1,2-epoxide; 7-MBA DE; 1,2-Epoxy-1,2,3,4-tetrahydro-7-methylbenz[a]anthracene-3,4-diol; PAH Metabolite (7-Methyl); 7-Methylbenz(a)anthracene diol epoxide
EINECS	Contact for details

Quality Control

Every batch of 7-Methylbenz(A)Anthracene 3,4-Dihydrodiol 1,2-Epoxide is synthesized and purified under controlled conditions to ensure the highest standards of identity and purity required for research applications. Our products undergo rigorous quality testing, including chromatographic purity analysis and structural confirmation, to ensure consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for identity, purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in DMSO, Acetone; sparingly soluble in Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.