Description

Spiro[Bicyclo[3.1.1]Heptan-3,1′-[2]Cyclohexen]-4′-On, 2,6,6-Trimethyl-, [1S-(1.Alpha,2.Beta,3.Beta,5.Alpha)]- is a high-purity, stereochemically defined spirocyclic ketone compound. This specialized intermediate is valued for its unique rigid molecular framework, which is critical for imparting specific structural and electronic properties in advanced synthesis. It is primarily sought after by R&D and production teams in the pharmaceutical and fine chemical industries for applications in chiral synthesis, fragrance development, and materials science research.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug research.
• Fragrance & Flavor Chemistry: Used in the development of complex, high-value aroma molecules, leveraging its camphoraceous and woody structural notes.
• Advanced Material Synthesis: Serves as a precursor for ligands and functional monomers in specialty polymers and liquid crystals.
• Asymmetric Catalysis: Employed in the preparation of chiral catalysts and auxiliaries for stereoselective transformations.
• Organic Synthesis Research: A valuable scaffold in academic and industrial R&D for exploring new chemical spaces and reaction methodologies.
• Agrochemical Intermediates: Potential use in the synthesis of advanced, targeted crop protection agents.

Basic Information

Product Name	Spiro[Bicyclo[3.1.1]Heptan-3,1′-[2]Cyclohexen]-4′-On, 2,6,6-Trimethyl-, [1S-(1.Alpha,2.Beta,3.Beta,5.Alpha)]-
CAS No.	133636-82-5
Molecular Formula	C15H22O
Molecular Weight	218.33 g/mol
Synonyms	(1S,2R,3R,5S)-2,6,6-Trimethylspiro[bicyclo[3.1.1]heptane-3,1'-cyclohex-2-en]-4'-one; (-)-2,6,6-Trimethylspiro[bicyclo[3.1.1]heptane-3,1'-cyclohex-2-en]-4'-one; Spiro[3.1.1]heptane-3,1'-cyclohex-2-en]-4'-one derivative; Chiral spirocyclic ketone; Pinane-derived spiro ketone
EINECS	Contact for details

Quality Control

Our Spiro[Bicyclo[3.1.1]Heptan-3,1′-[2]Cyclohexen]-4′-On, 2,6,6-Trimethyl-, [1S-(1.Alpha,2.Beta,3.Beta,5.Alpha)]- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.